Marburg virus disease, Ethiopia: Ethiopia reports no new Marburg virus disease cases over the past 21 days.
Bacillus cereus toxin, Global: Detection of Bacillus cereus-derived cereulide toxin in infant formula has prompted a precautionary global product recall affecting 49 countries. Clinicians should be alert to infants presenting with sudden-onset vomiting. Parents and caregivers should verify batch numbers and discontinue use of affected products.
MERS-CoV, Saudi Arabia: As of 5 January 2026, five new Middle East respiratory syndrome coronavirus (MERS-CoV) cases (including one fatality) have been reported in Saudi Arabia. Sporadic cases continue in the Arabian Peninsula with ongoing risk of international exportation via travel.
Dengue, Sri Lanka: Sri Lanka reports 2,170 dengue cases during the first days of 2026, indicating early and intense transmission. Travellers should employ personal protective measures against mosquito bites.
Seasonal Influenza A(H3N2), multi-country: Elevated influenza activity continues with concerning paediatric mortality. The United States reports 17 influenza-related paediatric deaths this season, Israel reports its sixth infant death, and Australia reports cases considerably higher than at the same time in previous seasons. Latin America reports increased seasonal influenza and RSV circulation across multiple countries.
Acute bacterial diarrhoea, India (Madhya Pradesh): A waterborne disease epidemic declared following severe sewage contamination of the municipal water system has resulted in approximately 3,200 cases and 17 deaths. Extensive multi-pathogen contamination was identified.
Ethiopia reports no new Marburg cases in 21 days. Five new MERS-CoV cases reported in Saudi Arabia, including one fatality. Nestlé recalls infant formula in 49 countries following detection of Bacillus cereus toxin. Sri Lanka reports 2,170 dengue cases in early January. Influenza activity remains elevated globally with 17 paediatric deaths in the US and continued high transmission in multiple regions. India declares waterborne disease epidemic in Indore with 3,200 cases and 17 deaths from sewage contamination.
The ESCMID-AUMC Epi Alert, a strategic collaboration between the ESCMID Emerging Infections Subcommittee and the Center of Tropical Medicine and Travel Medicine of Amsterdam University Medical Center (AUMC) that integrates expertise and resources to advance emerging infectious diseases surveillance and intelligence sharing. This collaboration integrates ESCMID's extensive international network and emerging infections expertise with AUMC's proven surveillance capabilities, led by Dr. Abraham Goorhuis and the AUMC team.
The Epi Alert aims for weekly publication, with frequency adapted to emerging threats. The briefings are curated by infectious disease specialists prioritising data from trusted sources (WHO, ECDC, CDC, ProMED) based on potential impact, geographic region and urgency/relevancy to clinical practice. It aims to provide concise summaries for busy healthcare professionals with direct links for further investigation and transparency.
This integrated collaboration represents a significant milestone in ESCMID's commitment to emerging infections preparedness, strengthening our collective capacity to detect, analyse, and respond to infectious disease threats through international cooperation.
Disclaimer: The information in this epi-alert is a weekly summary of the information that is available on the internet, mainly the websites of WHO, ECDC, CDC, and others. For this summary, we consider issues that are most relevant to the ESCMID members involved in clinical patient care. Therefore, this report is not comprehensive, but we strive to include all major global issues in this report on a weekly basis.
On 14 November 2025, Ethiopia confirmed its first outbreak of Marburg virus disease (MVD) in the South Omo Zone, Southern Ethiopia. This outbreak represents a significant epidemiological shift: Ethiopia has never previously reported MVD. Genetic sequencing suggests the strain is closely related to East African lineages, pointing to a regional reservoir. Laboratory testing identified Marburg virus in samples from a cluster of suspected haemorrhagic fever cases. To date, 10 cases have been reported, including five fatalities (CFR 50%), two among healthcare workers, highlighting the risk of nosocomial transmission. A total of 57 suspected cases have been investigated, including four in the past 24 hours.
The recent re-emergence of avian influenza (H5N1) in parts of Asia, including isolated human cases in Cambodia and India, highlights the need for continued vigilance. While sustained human-to-human transmission has not been observed, the current situation warrants close monitoring. Strengthening surveillance, improving poultry vaccination strategies, and promoting regional One Health collaborations can support risk assessment and management, including early containment efforts.
Since the previous update on 5 May 2025, and as of 12 May 2025, nine new MERS-CoV cases—including two deaths—have been reported by health authorities in Saudi Arabia, bringing the total number of cases this year to ten.
Seven of the recent cases were part of the same cluster in Riyadh, including one patient with no history of contact with camels and six healthcare workers who acquired nosocomial infections from that patient in early May.
The risk of sustained human-to-human transmission in Europe remains very low. However, the current MERS-CoV situation is concerning, as this rise in cases comes just two weeks ahead of the Mecca pilgrimage—a period typically associated with high international travel.
Since April 2012, and as of 12 May 2025, a total of 2,638 confirmed MERS cases—including 957 deaths—have been reported globally.
A Marburg virus disease (MVD) outbreak is evolving in Rwanda, East Africa. As of 7 October 2024, over 40 confirmed MVD cases have been reported, mainly in healthcare facilities in Kigali, with many healthcare workers affected. This outbreak represents a spread from known endemic areas to urban settings, including nosocomial transmission in Kigali hospitals. While outbreaks are typically limited to remote areas, this one spans across Rwanda, with potential for satellite cases and further spread. No vaccines or treatments are currently available.
This compilation includes the latest news, publications, and resources, covering recent developments such as vaccine distribution in Africa and WHO policy updates. It provides links to '2022-2024 Mpox Outbreak: Global Trends,' which features interactive dashboards and epidemiological data. This update offers a brief overview of the developments of the mpox situation for healthcare professionals, researchers, and policymakers.
As of August 2024, the world is facing a significant mpox outbreak, primarily affecting countries in Central and East Africa, particularly the Democratic Republic of the Congo (DRC) and neighbouring countries, with cases reported across several regions. The outbreak is characterised by the sustained human-to-human transmission of the clade I monkeypox virus (MPXV).
This ESCMID EIS mpox commentary provides up-to-date, evidence-based information on mpox (formerly known as monkeypox) for healthcare professionals, researchers, and public health officials.
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